Plymouth South High School, or PSHS, is a 4-year program with an academic curriculum that includes English/language arts,  foreign language, health education, mathematics, physical education, science, social studies, unified arts and virtual programs.

The Panthers athletics program offers fall, winter and spring sports as well as other clubs and activities such as band, dance team and drama club. In addition, there is a Vocational Technical Studies program that consists of 15 high-quality programs blended into the comprehensive academic environment.